Diagnosis of variant RARA translocation using standard dual-color dual-fusion PML/RARA FISH probes: An illustrative report.

STUDY AIM

To assess the diagnosis of APML with variant translocations using in standard dual-color dual-fusion PML/RARa FISH analysis complimented by karyotyping to detect these variant RARA translocations.

Methods

This is a report an individual case study of a 27-year old man with APML.

Results

This case study highlighted the importance of atypical FISH signal patterns in standard dual-color dual-fusion PML/RARA FISH analysis complimented by karyotyping to detect these variant RARA translocations.

Conclusion

This brief communication adds to the literature on this rare entity, highlighting the challenges in diagnosis and management, reiterating the poor prognosis associated with this entity.

It also highlights the importance of atypical FISH signal patterns in standard dual-color dual-fusion PML/RARa FISH analysis complimented by karyotyping to detect these variant RARA translocations.