First experience of the AML-Berlin-Frankfurt-Münster group in pediatric patients with standard-risk acute promyelocytic leukemia treated with arsenic trioxide and all-trans retinoid acid.
Creutzig U, Dworzak MN, … von Neuhoff N. Pediatr Blood Cancer 2017 Jan 23.
CONCLUSIONS: The data suggest that it is still unknown which strategy should be followed, either starting cautiously with ATO on day 10 or beginning earlier with ATRA and ATO together.
Very Severe Differentiation Syndrome in Low Risk Acute Promyelocytic Leukemia – A Peril of Differentiating Therapy.
Hecht A, Mezger J, … Lengfelder E. Dtsch Med Wochenschr 2017; 142 (2): 111-114.
CONCLUSIONS: The case illustrates the difficulty and dangers of APL induction therapy even with a favorable initial clinical presentation despite the generally low toxicity of new therapies.
Phenylarsine Oxide Can Induce The Arsenite-Resistance Mutant PML Protein Solubility Changes.
Jiang YH, Chen YJ, … Naranmandura H. Int J Mol Sci 2017; 18 (2): 247.
CONCLUSIONS: The authors found that PAO is capable of inducing mutant PML protein solubility changes and degradation, suggesting that PAO is a considerable agent for relapsed/refractory APL. However, further investigation is needed to determine the dose level and toxicity of PAO in vivo and in vitro more carefully for clinical practices.
Acute WT1-Positive Promyelocytic Leukemia With Hypogranular Variant Morphology, Bcr-3 Isoform Of PML-RARα And Flt3-ITD Mutation: A Rare Case Report.
Zhang X, Yang C, … Feng Y. Sao Paulo Med J 2017. Epub Jan 23, 2017.
CONCLUSIONS: The authors believe that high WT1 expression in APL cases indicates an adverse prognosis and should be considered in APL risk stratification. Although the clinical data for further validation is far from plentiful, WT1 inhibitor or WT1-specific cytotoxic cell therapy may be promising in cases of high-risk APL with WT1 overexpression.
RXRα ligand Z-10 induces PML-RARα cleavage and APL cell apoptosis through disrupting PML-RARα/RXRα complex in a cAMP-independent manner.
Xu L, Zeng Z, … Zhou H. Oncotarget 2017; 8 (7): 12311-12322.
CONCLUSIONS: RXRα ligand Z-10 and its derivatives could target both ATRA- sensitive and resistant APL cells through their distinct acting mechanism, and are potential drug leads for APL treatment.
Autophagy Contributes To 4-Amino-2-Trifluoromethyl-Phenyl Retinate-Induced Differentiation In Human Acute Promyelocytic Leukemia NB4 Cells.
Li Y, Li G, … Chen FH. Toxicol Appl Pharmacol 2017; 319: 1-11.
CONCLUSIONS: These results suggested that autophagy play an important role in ATPR-induced cell differentiation, which may provide a novel approach to cure APL patients.
Resistance to arsenic trioxide and retinoic acid therapy in acute promyelocytic leukemia.
Zhang X, Pan J. Ann Hematol 2017; 96: 707.
CONCLUSIONS: Previous studies have suggested that targeted PML-RARA removal is a fundamental event that enables ATRA-induced APL cell differentiation. PML mutation is identical to the one most commonly encountered in the PML-RARA fusion when resistance to ATO develops. This may explain why the use of ATO can induce remission in ATRA-resistance APL patients, while the prognosis of ATO-resistance APL patients are very poor.
Evaluation Of The Safety And Efficacy Of Recombinant Soluble Thrombomodulin For Patients With Disseminated Intravascular Coagulation Associated With Acute Leukemia: Multicenter Prospective Study By The Tohoku Hematology Forum.
Yokoyama H, Takahashi N, … Tohoku Hematology Forum. Int J Hematol 2017 Feb 07.
CONCLUSIONS: These results suggest that rTM may improve the survival of acute leukemia patients with DIC by inhibiting early death related to hemorrhagic events, as reported previously.
Diagnosis of variant RARA translocation using standard dual-color dual-fusion PML/RARA FISH probes: An illustrative report.
Singh MK, Parihar M, … Chandy M. Hematol Oncol Stem Cell Ther 2017 Feb 01.
CONCLUSIONS: This case highlights the importance of atypical FISH signal patterns in standard dual-color dual-fusion PML/RARa FISH analysis complimented by karyotyping to detect these variant RARA translocations.
Arsenic sulfide induces apoptosis and autophagy through the activation of ROS/JNK and suppression of Akt/mTOR signaling pathways in osteosarcoma.
Wang G, Zhang T, … Cai Z. Free Rad Biol Med 2017; 106: 24-37.
CONCLUSIONS: The results revealed that As2S2 induced G2/M phase arrest, apoptosis, and autophagy via activing ROS/JNK and blocking Akt/mTOR signaling pathway in human osteosarcoma cells and thus arsenic sulfide may be a potential clinical antitumor drugs targeting osteosarcoma.
Literature Review
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